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You Are Here: Home - March 2009 Focus - Earthworm References

March 2009 Focus - Earthworm References
ARG Focus Newsletter

Earthworm References

Back to New Enzyme Complex Isolated From Earthworms Is Potent Fibrinolytic

J. W. Reynolds, W.M. Reynolds, Earthworms in Medicine, American Journal of Nursing, 72, 1273-1274.

J. Stevenson, Oligochaeta. Claredon Press Oxford, 1930, pp. 658-659.

G.E. Gates, The Earthworms of Rangoon, J. Burma Res. Soc. 25, 196-221 (1926).

H.S. Bristowe, Insects and other invertebrates for human consumption in Siam, Trans. Entomol. Soc. 80, 387-404 (1932).

L.G.K Carr, Interesting animal foods, medicines and omens of the eastern Indians, with comparisons to ancient European practices, J. Wash. Acad. Sci. 41, 229-235 (1951).

S. F. Price, Kentucky Folklore, J Am Folklore. 14, 30-38 (1901).

The Eu Yan Sang Heritage An Anthology of Chinese Herbs and Medicines.  Eu Yan Sang International Holdings Pte Ltd, 269A South Bridge Road, Singapore 05818.

R. Fan, The new medicine "lumbrokinase capsules" for treatment and prevention of thrombus and imbolicdiseases, pp. 1-7 [Institute of Biophysics, Academia Sinica, Beijing Bio Pharmaceuticals Co. Ltd. 15 Datun Road, Beijing 100101 CHINA] (Personal Communication through Dr. Z. Zhang, National Laboratory of Molecular Virology and Genetic Engineering, Beijing CHINA). (1996)

D.S. Linthicum, E.A. Stein, D.H. Marks, and E.L. Cooper, Electron microscopic observations of normal coelomocytes from the earthworm Lumbricus terrestris, Cell and Tissue Res., 185, 315-330 (1977).

E. A. Stein, R.R. Avtalion, and E.L. Cooper, The coelomocytes of the earthworm Lumbricus terrestris: morphology and phagocytic properties, J. Morphol. 153, 467-477. (1977). 

E.A. Stein, A. Wojdani, and E.L. Cooper, Agglutinins in the earthworm Lumbricus terrestris: naturally occurring and induced, Dev. Comp. Immunol., 6, 407-421 (1982). 

E.A. Stein, S. Younai, and E.L. Cooper,  Bacterial agglutinins of the earthworm Lumbricus terrestris, Comp. Biochem. Physiol., 84: 409-415.

E.A. Stein and E.L. Cooper,. In vitro agglutinin production by earthworm leukocytes, Dev. Comp. Immunol. 12, 531-547 (1988).

E.A. Stein, A. Morovati, P. Rahimian, and E.L. Cooper, Lipid agglutinins from coelomic fluid of the earthworm Lumbricus terrestris, Comp. Biochem. Physiol., 94B, 703-707 (1989)

E.A. Stein, S. Younai, E.L. Cooper, Separation and partial purification of agglutinins from coelomic fluid of the earthworm, Lumbricus terrestris, Comp. Biochem. Physiol. 97, 701-705 (1990).

E.A. Stein, and E.L. Cooper, Cytochemical observations of coelomocytes from the earthworm, Lumbricus terrestris, J. Histochem, 10, 657-678 (1978).

E.A. Stein, and E.L. Cooper, The role of opsonins in phagocytosis by coelomocytes of the earthworm, Lumbricus terrestrisDev. Comp. Immunol. 5, 15-25 (1981).

E.A. Stein, and E.L. Cooper, Carbohydrate and glycoprotein inhibitors of naturally occurring and induced agglutinins from the earthworm, Lumbricus terrestris, Comp. Biol. Chem. 76B, 197-206 (1983).

A. Wojdani, E.A. Stein, E.L. Cooper, and L.J. Alfred, Agglutinins and proteins in the earthworm, Lumbricus terrestris, before and after injection of erythrocytes, carbohydrates and other materials, Dev. Comp. Immunol. 6, 613-624 (1982).

P. Roch, E.L. Cooper, and D.P. Eskinazi, Serological evidences for a membrane structure related to human 2-microglobulin expressed by certain earthworm leukocytes, Eur. J. Immunol. 13, 1037-1042 (1983).

A.H. Saad, and E.L. Cooper, Evidence for a Thy-1 like molecule expressed on earthworm leukocytes.  Zool. ScI. 7, 217‑222 (1990).

E.L. Cooper, A. Cossarizza, M.M. Suzuki, S. Salvioli, M. Capri, D. Quaglino, C. Franceschi, Autogeneic but not allogeneic earthworm effector coelomocytes kill the mammalian tumor target K562, Cell. Immunol. 166, 113-122 (1995).

A. Cossarizza, E.L. Cooper, M.M. Suzuki, S. Salvioli, M. Capri, M., G. Gri, D. Quaglino, C. Franceschi, Earthworm leukocytes that are not phagocytic and cross-react with several human epitopes can kill human tumor cell lines, Exp. Cell Res. 224, 174-182 (1996).

D. Quaglino, E.L. Cooper, S. Salvioli, M. Capri, M.M. Suzuki, I. Pasquali-Ronchetti, C. Franceschi, A. Cossarizza, Earthworm coelomocytes in vitro: cellular features and “granuloma” formation during cytotoxic activity against the mammalian tumor cell target K562, Eu. J. Cell Biol. 70, 278-288 (1996).

E. Kauschke, P. Pagliara, L. Stabili, E.L. Cooper, Characterization of proteolytic activity in coelomic fluid of Lumbricus terrestris L. (Annelida, Lumbricidae), Comp. Biochem. Physiol. 116B, 235-242 (1997).

S. Lange, F. Nussler, E. Kauschke, G. Lutsch, E.L. Cooper, A. Herrmann, Interaction of earthworm hemolysin with lipid membranes requires sphingolipids, J. Biol. Chem. 272, 20884-20892 (1997).

S. Lange, E. Kauschke, W. Mohrig, E.L. Cooper, Biochemical characteristics of eiseniapore, a pore forming protein in the coelomic fluid of earthworms, Eur. J. Biochem. 263, 1-11 (1999).

Ph. Roch, P. Ville, E.L. Cooper, Characterization of a 14 kDa plant-related serine protease inhibitor and regulation of cytotoxic activity in earthworm coelomic fluid, Dev. Comp. Immunol. 22, 1-12 (1998).

I. Eue, E. Kauschke, W. Mohrig, E.L. Cooper, Isolation and characterization of earthworm hemolysins and agglutinins, Dev. Comp. Immunol. 22, 13-25 (1998).

V. Vetvicka, P. Sima, E.L. Cooper, M. Bilej, Ph. Roch, Immunology of Annelids (CRC Press, Boca Raton, 1994), p. 300.

E. Kauschke, and W. Mohrig, Cytotoxic activity in the coelomic fluid of the annelid Eisenia foetida., J. Comp. Physiol. B. 157, 77-83 (1987).

F. Hirigoyenberry, F. Lassalle, M. Lassegues, Antibacterial activity of Eisenia fetida andrei coelomic fluid: transcription and translation regulation of lysozyme and proteins evidenced after bacterial infestation., Comp. Biochem. Physiol. 95B, 71-75 (1987).

A. Wojdani, E.A. Stein, L.J  Alfred, E. L. Cooper, Mitogenic effect of earthworm (Lumbricus terrestris) coelomic fluid on mouse and human lymphocytes. Immunobiology 166, 157-167 (1984).

R. Hanusova, M Bilej, L. Brys, P. De Baetselier, A. Beschin, Identification of a coelomic mitogenic factor in Eisenia foetida earthworm, Immunol. Lett. 65, 203-311 (1990).

M. Lassègues, A. Milochau, F. Doignon, L. Du Pasquier, P. Valembois, Sequence and expression of an Eisenia foetida derived cDNA clone that encodes the 40 kDa fetidin antibacterial protein,. Eur. J. Biochem.246, 756-762 (1997).

Ph. Roch, E.L Cooper, E.L. Invertebrate immune responses: cells and molecular products, Adv. Comp. Env. Physiol. 23, 116-145 (1996).

P. Valembois, Ph. Roch, D. Boiledieu, in:  Phylogeny of Immunological Memory, edited by M.J. Manning (Elsevier Biomedical Press, North-Holland, 1980), pp. 47-55.

P. Valembois, Ph Roch, L. Du Pasquier, in:  Aspects of developmental and comparative immunology, edited by J. B. Solomon (Pergamon Press, Oxford, 1980), pp. 23-30.

E. L. Cooper, and Ph. Roch, Earthworm leukocyte interactions during early stages of graft rejection, J. Exp. Zool. 232, 67-72 (1984).

F. Lassalle, M. Lassegues, Ph. Roch, Protein analysis of earthworm coelomic fluid. IV. Evidence, activity, induction and purification of Eisenia fetida andrei lysozyme, Comp. Biochem. Physiol. 91, 187-192 (1988).

P. Valembois, J. Seymour, Ph. Roch, Evidence and cellular localization of an oxidative activity in the coelomic fluid of the earthworm Eisenia fetida andrei, J. Invert. Pathol. 57, 177-183 (1991).

Ph. Roch, P. Valembois, N. Davant, M. Lassegues, Protein analysis of earthworm coelomic fluid. Isolation and biochemical characterization of the Eisenia fetida andrei factor (EFAF), Comp. Biochem. Physiol. 69, 829-836 (1981).

A. Milochau, M. Lassegues, P. Valembois, Purification, characterization and activities of two hemolytic and antibacterial proteins from coelomic fluid of the annelid Eisenia fetida andrei, Biochem. Biophys. Acta.1337, 123-132 (1997).

H. Mihara, H. Sumi, T. Yoneta, H. Mizumoto, R. Ikeda, M. Seiki, M. Maruyama, A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus, Jpn. J. Physiol 41, 461-472 (1991).

H. Mihara, M. Maruyama, H. Sumi, Novel thrombolytic therapy discovered from traditional oriental medicine using the earthworm, Southeast Asia J. Trop. Med. Public Health. 23,131-140 (1992).

U. Rester, I. Bode, M. Moser, M.A.A. Parry, R. Huber,  E. Auerswald, Structure of the complex of the antistasin-type inhibitor bdellastasin with trypsin and modeling of the bdellastasin-microplasmin system, J. Mol. Biol. 293, 93-106 (1999).

N. Nakajima, H. Mihara, H. Sumi, Characterization of potent fibrinolytic enzymes in earthworm, Lumbricus rubellus, Biosci. Biotechol. Biochem. 10, 1726-1730 (1993).

N. Nakajima, K. Ishihara, M. Sugimoto, H.  Sumi, K. Mikuni, H. Hamada, Chemical modification of earthworm fibrinolytic enzyme with human serum albumin fragment and characterization of the protease as a therapeutic enzyme, Biosci. Biotechnol. Biochem. 60, 293-300 (1996).

Z.X. Zhang, F.F. Wang, Effects of crude extract of earthworm on promoting blood circulation to removing stasis, Chung Kuo Chung His I Chieh Ho Tsa Chih. 12, 741-743, 710 (1992).

K.M. Woo, W. Yi, Y.J. Sohn, C.S. Chang, M.S. Kang, D.B. Ha, C.H. Chung, Purification and characterization of a poly-L-lysine-activated serine endoprotease from Lumbricus rubellus. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 1, 71-80 (1994).

G.H. Ryu, S. Park, M. Kim, D.K. Han, Y.H. Kim, B. Min, Antithrombogenicity of lumbrokinase-immobilized polyurethane, J. Biomed. Mater. Res. 28, 1069-1077 (1994).

G.H. Ryu, Surface characteristic and properties of lumbrokinase-immobilized polyurethane, J. Biomed. Mater. Res. 29, 403-409 (1995).

Y.S. Kim, M.K. Pyo, K.M Park, B.S. Hahn, K.Y. Yang, H.S. Yun-Choi, Dose dependency of earthworm powder on antithrombotic and fibrinolytic effects, Arch. Pharm. Res. 4, 374-377 (1998).

Y. Xiong, S.C. Yang, X.Y. Liu, L.Y. Li, B.G. Ru,  Purification and etermination of partial sequence of Earthworm Fibrinolytic enzyme, Chinese Biochemical Journal, 13, 292-296(1997)

B.D. Xing, S.M. Yin, B.G. Ru, Purification and characterization of the fibrinolytic enzyme (eFE-D) from earthworm Eisenia fetida, Acta Biochim. Biophys. Sinica. 29, 609-612 (1997).

J.S. Yang, B.G. Ru, Purification and Characterization of an SDS-Activated Fibrinolytic Enzyme from Eisenia fetida, Comp. Biochem. Physiol. 118B, 623-631 (1997).

J.S. Yang, L.Y. Li, B.G. Ru, Purification of a Plasminogen Activator from Eisenia fetida, Chinese Journal of Biochemistry and Molecular Biology. 14, 156-163 (1998a).

J.S. Yang, L.Y. Li, B.G. Ru, Characterization of a Plasminogen Activator from Eisenia fetida, Chinese Journal of Biochemistry and Molecular Biology. 14, 156-169 (1998b).

J.S. Yang, L.Y. Li, B.G. Ru, Degradation of Benzoyl-L-argiflifle Ethyl Ester (BAEE) by a Plasminogen Activator from Eisenia fetida (e-PA), Chinese Journal of Biochemistry and Molecular Biology. 14, 412-416 (1998c).

J.S. Yang, L.Y. Li, B.G. Ru, Degradation of N-Acetyl-L-tyrosine Ethyl Ester (ATEE) by a Plasminogen Activator from Eisenia fetida (e-PA) Chinese Journal of Biochemistry and Molecular Biology. 14, 417-421 (1998d).

J.S. Yang, L.Y. Li, B.G. Ru, The enzymology properties and the CD spectra of the active centers of the small subunit of a plasminogen activator from Eisenia fetida (e-PA), Chinese Journal of Biochemistry and Molecular Biology. 14, 721-725 (1998e).

T. Hrzenjak, M. Popovic, L. Tiska-Rudman, Fibrinolytic activity of earthworm's extract (G-90) on lysis of fibrin clots originated from the venous blood of patients with malignant tumor, Pathol. Onco. Res. 4, 206-211 (1998).

C. Leipner, L.Tuckova, J. Rejneck, J. Langner, Serine proteases in coelomic fluid of annelids Eisenia fetida and Lumbricus terrestris, Comp. Biochem. Physiol.105, 637-641 (1993).

A. Polanowski, and T. Wilusz, Serine proteinase inhibitors from insect hemolymph, Acta. Biochem. Polinica. 43, 445-454 (1996).

Ph. Roch, Protein analysis of earthworm coelomic fluid. I. Polymorphic system of the natural hemolysin of Eisenia fetida andrei. Dev. Comp. Immunol. 3, 599-608 (1979).

Ph. Roch, C. Canicatti, P. Valembois, Interactions between earthworm hemolysins and sheep red blood cell membranes. Biochem. Biophys. Acta. 983, 193-198 (1989).

P. Valembois, Ph. Roch, M. Lassegues, N. Davant, Bacteriostatic activity of a chloragogen cell secretion, Pedobiologia. 24, 191-195 (1982).

P. Valembois, Ph. Roch, M. Lassegues, Evidence of plasma clotting system in earthworms. J. Invert. Pathol. 15, 221-228 (1988).

P. Valembois, M. Lassegues, Ph. Roch, J. Vaillier, Scanning electron-microscopic study of the involvement of coelomic cells in earthworm antibacterial defense, Cell Tissue Res. 240, 479-484 (1985).

J.H. Cho, C.B. Park, Y.G. Yoon, S.C. Kim, Lumbricin I a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization. Biochim. Biophy. Acta. 1408, 67-76 (1998).

Y. Sekizawa, T. Kubo, H. Kobayashi, T. Nakajima, S. Natori,Molecular cloning of cDNA for lysenin, a novel protein in the earthworm, Eisenia foetida that causes contraction of rat vascular smooth muscle, Gene. 191, 97-102 (1997).

A. Yamaji, Y. Sekizawa, K. Emoto, H. Sakuraba, K. Inoue, H. Kobayashi, M. Umeda, Lysenin, a novel sphingomyelin-specific binding protein, J. Biol. Chem. 273, 300-5306, (1988).

N. Ohta, S. Shioda, Y. Sekizawa, Y. Nakai, H. Kobayashi, Sites of expression of mRNA for lysenin, a protein isolated from the coelomic fluid of the earthworm Eisenia foetida, Cell Tissue Res. 302, 263-270 (2000). 

H. Kobayashi, Y. Sekizawa, M. Aizu, M. Umeda, Lethal and non-lethal responses of spermatozoa from a wide variety of vertebrates and invertebrates to lysenin, a protein from the coelomic fluid of the earthworm Eisenia foetida, J. Exp. Zool. 286, 538-549 (2000).

H. Kobayashi, M. Ohtomi, Y. Sekizawa, N. Ohta, Toxicity of coelomic fluid of the earthworm Eisenia foetida to vertebrates but not invertebrates: probable role of sphingomyelin, Comp. Biochem. Physiol. 128C, 401-411 (2001).

A. Beschin, M. Bilej, E. Torreele, P. De Baetselier, On the existence of cytokines in invertebrates, Cell. Mol. Life Sci. 58, 801-814 (2001).

M. Bilej, L. Brys, A. Beschin, R. Lucas, E. Vercauteren, R. Hanusova, P. De Baetselier, Identification of a cytolytic protein in the coelomic fluid of Eisenia foetida earthworms, Immunol. Lett. 45, 123-128 (1995).

A. Beschin, M. Bilej, F. Hanssens, J. Raymakers, E. Van Dyck, H. Revets, L. Brys, J. Gomez, P. De Baetselier, M. Timermans, Identification and cloning of a glucan- and lipopolysaccharide-binding protein from Eisenia foetida earthworm involved in the activation of prophenoloxidase cascade, J. Biol. Chem. 273, 24948-24954 (1998).

M. Bilej, P. Rossmann, M. Sinkora, R. Hanusova, A Beschin, G. Raes, P. De Baetselier, Cellular expression of the cytolytic factor in earthworms Eisenia foetida. Immunol. Lett. 60, 23-29 (1998).

M. Bilej, P. De Baetselier, Beschin, A. Antimicrobial defense of earthworm, Folia Microbiol. 45, 283-300 (2000).

M. Bilej, P. De Baetselier, E. Van Dijck, B. Stijlemans, A. Colige, A. Beschin, Distinct carbohydrate recognition domains of an earthworm defense molecule recognize Gram negative and Gram-positive bacteria, J. Biol. Chem. 276, 45840-45847 (2001).

A. Beschin, M. Bilej, L. Brys, E. Torreele, R. Lucas, S. Magez, P. De Baetselier, Convergent evolution of cytokines, Nature. 400, 627-628 (1999).

A. Bloc, R. Lucas, E. Van Dijck, M. Bilej, Y. Dunant, P. De Baetselier, A. Beschin, An invertebrate defense molecule activates membrane conductance in mammalian cells by means of its lectin-like domain, Dev. Comp. Immunol. 26,35-43 (2002).

E. Olivares, E. Fontt, A. Beschin, E. Van Dijck, V. Vercruysse, M. Bilej, R. Lucas, P. De Baetselier, B. Vray, Trypanosoma cruzi is lysed by coelomic cytolytic factor-1, an invertebrate analogue of TNF, and induces phenoloxidase activity in the coelomic fluid of Eisenia foetida, Dev. Comp. Immunol. 26, 27-34 (2002).

E.L. Cooper, Phylogeny of cytotoxicity Endeavor 4, 160-165 (1981).

E.L. Cooper, in:  Immunology of Annelids, edited by V. Vetvicka et al (CRC Press, Boca Raton 1994), pp. 1-12.

E.L. Cooper, in:  Invertebrate Immunology, edited by B. Rinkevich and W.E.G. Müller (Springer-Verlag, Heidelberg, 1996), pp. 10-45.

H. Nagasawa, K. Sawaki, Y. Fujii, M. Kobayashi, T. Segawa, R. Suzuki, H. Inatomi, Inhibition by lombricine from earthworm (Lumbricus terrestris) of the growth of spontaneous mammary tumors in SHN mice. Anticancer Research. 11, 1061-1064 (1991).

T.M. Hrzenjak, M. Popovic, T. Bozic, M. Grdisa, D. Kobrehel, L. Tiska-Rudman, Fibrinolytic and anticoagulative activities from the earthworm Eisenia foetida, Comp. Biochem. Physiol. 119B, 825-832 (1998b).

T. Hrzenjak, M. Hrzenjak, V. Kasuba, P. Efenberger-Marinculic, S. Levanat, A new source of biologically active compounds earthworm tissue (Eisenia foetida, Lumbricus rubellus), Comp. Biochem. Physiol. 102A, 441-447 (1992).

M. Hrzenjak, D. Kobrehel, S. Levanat, M. Jurin, T. Hrzenjak, Mitogenicity of the earthworm’s (Eisenia foetida) insulin-like proteins, Comp. Biochem. Physiol. 104B, 723-729 (1993).

M. Popovic, T.M. Hrcenjak, T. Babic, J. Kos, M. Grdisa, Effect of earthworm (G-90) extract on formation and lysis of clots originated from venous blood of dogs with cardiopathies and with malignant tumors, Pathol Oncol Res. 7, 197-202 (2001).

J.B. Xie, N. Weng, W.G. He, M.M. Yu, B.G. Ru, Antitumor activity and partial characterization of the extract from earthworm Eisenia fetida. Chinese Journal of Biochemistry and Molecular Biology, in press (2003).

J.B. Xie, N. Weng, W.G. He, M.M. Yu, B.G. Ru,Purification, identification and partial characterization of antitumor related Serine Protease Eisenin I. Progress in Biochemistry and Biophysics, in press (2003).

J.B. Xie,, N. Weng, B.G. Ru, Cloning and analysis of antitumor related Serine Protease Eisenin I mRNA sequence, Progress in Biochemistry and Biophysics, (in preparation).

PGresele, and G. Agnelli, Novel approaches to the treatment of thrombosis, Trends in Pharmacological Sciences 23, 25-32 (2001).

H.V. Anderson, J.T. Willerson, Thrombolysis in acute myocardial infarction, N. Engl. J. Med. 329, 703-709 (1993).

R. Pannell, and V. Gurewich, Pro-urokinase: A study of its stability in plasma and of a mechanism for its selective fibrinolytic effect, Blood. 67, 1215-1223 (1986).

V. Gurewich, R. Pannell, S. Louie, P. Kelley, R.L. Suddith, R. Greenlee, Effective and fibrin-specific clot lysis by a zymogen precursor form of urokinase (pro-urokinase): a study in vitro and in two animal species, J. Clin. Invest. 73, 1731-1739 (1984).

R. Pannell, J. Black, V. Gurewich, The complementary modes of action of tissue-type plasminogen activator and pro-urokinase by which their synergistic effect on clot lysis may be explained, J Clin Invest. 81, 853-859 (1988).

H.G. Boman, Peptide antibiotics and their role in innate immunity, Annu. Rev. Immunol. 13 (1995) 61^92.
P. Nicolas, A. Mor, Peptides as weapons against microorganisms in the chemical defense system of vertebrates, Annu. Rev. Microbiol. 49 (1995) 277^304.

E.A. Stein, A. Wojdani, E.L. Cooper, Agglutinins in the earthworm Lumbricus terrestris: naturally occurring and induced, Dev. Comp. Immunol. 3 (1982) 407^422.

P. Valembois, P. Roch, M. Lassègues, P. Cassand, Antibacterial activity of hemolytic system from the earthworm Eisenia fetida andrei, J. Invest. Pathol. 40 (1982) 21^27.

F. Lassalle, M. Lassègues, P. Loach, Protein analysis of earthworm coelomic fluid IV. Evidence, activity, induction and purification of Eisenia fetida andrei lysozyme (Annelida), Comp. Biochem. Physiol. 91B (1988) 187^192.

F. Hirigoyenberry, F. Lassalle, M. Lassègues, Antibacterial activity of Eisenia fetida andrei coelomic £uid: transcription and translation regulation of lysozyme and proteins evidenced after bacterial infection, Comp. Biochem.  Physiol. 95B (1990) 71^75.

A. Milochau, M. Lassègues, P. Valembois, Purification, characterization and activities of two hemolytic and antimicrobial proteins from coelomic £uid of the annelid Eisenia fetida andrei, Biochim. Biophys. Acta 1337 (1997) 123^ 132.

Ju Hyun Cho, Chan Bae Park, Young Geol Yoon. Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization. Biochimica et Biophysica Acta 1408 (1998) 67^76

ZHANG Xi-Chun ,SUN Zhen-Jun , ZHUO Ru-Peng. Purification and characterization of two antibacterial peptide from the annelid Eisenia fetida. Prog. Biochem. Biophys. 2002, 29(6):955-960

Xin Wang, Xiaoxu Wang, Yi Zhang. An antimicrobial peptide of the earthworm Pheretima tschiliensis: cDNA cloning, expression and immunolocalization.Biotechnology Letters25: 1317–1323, 2003.

Cooper EL, Kauschke E, Cossarizza A (2002) Digging for innate immunity since Darwin and Metchnikoff. BioEssays 24: 319–333.

Zhangxichun. Purification and characterization of two antibacterial peptides from earthworm  Eisenia fetida. Ph. D. Dissertation. Chian Agricultural University, Beijing, 2002

Sekizawa Y, Kubo T, Kobayashi H, Nakajima T. Molecular cloning of cDNA for lysenin, a novel protein in the earthworm Eisenia foetida that causes contraction of rat vascular smooth muscle. Gene, 1997, 191: 97–102.

Saberwal G, Nagaraj R. Cell lytic and antibacterial peptides that by perturbing the barrier function of membranes: facets of their conformational features, structure-function correlations and membrane perturbing abilities. Biochem. Biophys. Acta, 1994, 1197:109-131

Javadpour M, Barkley MD. Selfassembly of designed antimicrobial peptides in solution and micelles. Biochemistry, 1997, 36:9540-9549

G. Vanhoof, F. Goossens, D.I. Meester, D. Hendriks, S. Scharpe®, Proline motifs in peptides and their biological processing, FASEB J. 9 (1995) 736^744.

P. Casteels, C. Ampe, F. Jacobs, M. Vaeck, P. Tempst, Apidaecins: antimicrobial peptides from honeybees, EMBO J. 8 (1989) 2387^2391.

P. Bulet, J.L. Dimarcq, C. Hetru, M. Lagueux, M. Charlet, G. Hegy, A.V. Dorsselaer, J.A. Ho°mann, J. Biol. Chem. 268 (1993) 14893^14897.

E.A. Levashina, S. Ohresser, P. Bulet, J.M. Reichhart, C. Hetru, J.A. Ho°mann, Eur. J. Biochem. 233 (1995) 694^700.

R.W. Frank, R. Gennaro, K. Schneider, M. Przybylski, D. Romeo, Amino acid sequence of two proline-rich bactenecins, J. Biol. Chem. 265 (1990) 18871^18874.

B. Agerberth, J.Y. Lee, T. Bergman, M. Carlquist, H.G. Boman, V. Mutt, H. Jornvall, Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides, Eur. J. Biochem. 202 (1991) 849^854.

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