Supports a Key Pathway for Cellular Defense and Detoxification*
What It Does
Nrf2 Renew® is a botanical and nutrient formula designed to activate the Nrf2 cellular defense pathway, a key regulator of antioxidant and detoxification gene expression.* This pathway plays a central role in helping the body respond to oxidative stress and environmental challenges while promoting internal balance and cellular resilience.* [21,22]
How It Works
• Sulforaphane (from broccoli sprout extract): A powerful activator of the Nrf2 pathway shown to support mitochondrial function, antioxidant enzyme production, and detoxification activity.*[1-4]
• Green Tea Extract: Containing catechins, green tea has been shown to upregulate Nrf2 activity, promoting antioxidant defenses and supporting metabolic, cardiovascular, and immune health.*[5-7]
• Green Coffee Extract: Supplies polyphenols that enhance Nrf2-mediated cellular defense mechanisms and contribute to healthy oxidative balance.*[8-11]
• Pomegranate Extract: Provides polyphenols that activate Nrf2 and support a healthy cytokine response, circulation, and vascular health.*[12-15]
• Olive Leaf Extract: Demonstrated to upregulate antioxidant genes through Nrf2 activation, supporting healthy oxidative stress markers and glutathione-related enzymes.*[16-18]
• Ginkgo biloba Extract: Delivers flavonoids and terpene trilactones that promote cellular health and antioxidant response via the Nrf2 pathway.*[19]
• Milk Thistle (Silybum marianum): Contains silymarin, a flavonoid complex shown to promote Nrf2 pathway activity and enhance the body’s natural detoxification capacity.*[20]
Who It’s For
Ideal for individuals seeking broad-spectrum antioxidant activity, particularly those looking to enhance their cellular defenses, detoxification capacity, and resilience to oxidative and metabolic stress.*
Special Features
Nrf2 Renew® combines some of the most studied Nrf2-activating botanicals and nutrients in an elegant formula, backed by multiple clinical and preclinical studies. It delivers support for maintaining redox balance, mitochondrial integrity, and systemic resilience.*
References
1. Houghton CA, et al. Oxid Med Cell Longev. 2016;2016(1). doi:10.1155/2016/7857186
2. O’Mealey GB, et al. Redox Biology. 2016;11:103–0.
3. Napoli E, et al. Neurobiol Dis. 2021;157:105427. doi:10.1016/j.nbd.2021.105427
4. Jardim FR, et al. J Zhejiang Univ Sci B. 2020;21(4):263–79.
5. Wang D, et al. Front Nutr. 2022;9. doi:10.3389/fnut.2022.836112
6. Khan IM, et al. Poultry Sci. 2025;104(5):105071
7. Rasaei N, et al. Antioxidants. 2021;10(11):1731. doi:10.3390/antiox10111731
8. Rizk S, et al. Metab Brain Dis. 2021;36(7):1943–56.
9. Affonso RCL, et al. Oxid Med Cell Longev. 2016;2016(1). doi:10.1155/2016/1923754
10. Lonati E, et al. Molecules. 2022;27(3):1049. doi:10.3390/molecules27031049
11. Pourmasoumi M, et al. Adv Exp Med Biol. 2021:323–45.
12. Sun W, et al. Sci Reports. 2016;6(1). doi:10.1038/srep34246
13. Asgary S, et al. Adv Biomed Res. 2014;3(1):100. doi:10.4103/2277-9175.129371
14. Aviram M, et al. Am J Clin Nutr. 2000;71(5):1062–76. doi:10.1093/ajcn/71.5.1062
15. Giménez-Bastida JA, et al. Trends Food Sci Technol. 2021;114:410–23.
16. Castejon ML, et al. J Nutr Biochem. 2019;74:108229. doi:10.1016/j.jnutbio.2019.108229
17. Silvestrini A, et al. Antioxidants. 2023;12(8):1509. doi:10.3390/antiox12081509
18. Pojero F, et al. Int J Mol Sci. 2022;24(1):380. doi:10.3390/ijms24010380
19. Li Y, et al. J Pharm Pharmacol. 2022;74(12):1689–99.
20. Vargas-Mendoza N, et al. Biomedicines. 2020;8(5):122. doi:10.3390/biomedicines8050122
21. He F, et al. Int J Mol Sci. 2020;21(13):4777. doi:10.3390/ijms21134777
22. Morgenstern C, et al. Redox Biology. 2024;72:103134. doi:10.1016/j.redox.2024.103134
