• Berberine HCl (97%): A concentrated, plant-derived alkaloid that supports healthy blood glucose and lipid metabolism.*
• AMPK Activation: Berberine activates AMP-activated protein kinase (AMPK), an enzyme that regulates glucose uptake, fat metabolism, and energy balance.*[1]
• Blood Sugar Support: A meta-analysis of 37 studies involving 3,048 participants demonstrated berberine's ability to support glucose regulation without increasing the risk of hypoglycemia.*[2]
• Lipid Metabolism: Berberine has been shown in placebo-controlled trials to support cholesterol and triglyceride balance, promote a healthy HDL to LDL ratio, and enhance lipid oxidation through AMPK activation.*[3,4,7]
• Healthy Weight Management: In a six-month clinical trial, 500 mg twice daily helped maintain healthy weight and cardiometabolic markers in participants with metabolic concerns.*[3]
• Gut Microbiome Balance: Berberine supports a healthy gut microbiota, which contributes to glucose, lipid, and immune system regulation.*[5,6]
• Dosages: In a meta-analysis examining the effects of berberine on metabolic parameters, the most common dosage used across the included studies was 500 mg taken three times daily (1.5 g daily). Other dosing approaches were also represented, including lower daily doses such as 300 mg twice or thrice daily as well as higher doses ranging from 500 mg twice daily up to 1,000 mg three times daily.*[8]
