Homocysteine Plus delivers activated methyl donors and essential cofactors to support healthy methylation, cardiovascular function, and antioxidant balance.* This formula provides primary nutrients to facilitate the breakdown of homocysteine into methionine and other metabolites, including coenzyme forms of vitamins B2, B6, folate, and B12, plus Setria® glutathione, zinc, trimethylglycine, and L-serine.*
As a dietary supplement, take 1 capsule daily with meals, or as directed by a healthcare practitioner.
Warning:
If you are pregnant or lactating, have any health condition or are taking any medication, consult your healthcare practitioner before use.
Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.
Ingredients:
Serving Size: 1 capsule Servings Per Container: 90
Amount per serving:
Riboflavin (as Riboflavin-5-Phosphate): 10 mg Vitamin B6 (50% as Pyridoxine HCl and 50% as Pyridoxal-5-Phosphate): 30 mg Folate (as 400 mcg of 5-Methyltetrahydrofolate [from 740 mcg [6S]-5-methyltetrahydrofolate acid, glucosamine salt]): 667 mcg DFE Vitamin B12 (as Methylcobalamin): 400 mcg Zinc (Zinc Picolinate): 5 mg Trimethylglycine: 500 mg L-Serine: 100 mg L-Glutathione (reduced): 50 mg
Methylation Support for Homocysteine and Cellular Health*
What It Does
Homocysteine Plus provides broad-spectrum nutritional support for methylation and detoxification pathways that help maintain healthy homocysteine levels.* By supplying bioavailable methyl donors and cofactors, this formula supports cardiovascular, neurological, and cellular antioxidant function.*
How It Works
• L-methylfolate supplies activated folate to support the methionine cycle, bypassing MTHFR polymorphisms.*[3-4]
• Methylcobalamin is the bioactive form of vitamin B12, directly participating in methylation reactions required for homocysteine metabolism.*
• Trimethylglycine (betaine) supports homocysteine-to-methionine conversion via the BHMT pathway, a folate-independent route active in the liver and kidneys.*
• Serine contributes methyl groups for folate regeneration and promotes cysteine and taurine production for downstream antioxidant support.*[6]
• Zinc is a cofactor for both methionine synthase and BHMT enzymes that catalyze the remethylation of homocysteine.*[1]
• Vitamin B6 supports both the folate and transsulfuration pathways, supporting cysteine and glutathione synthesis.*[5]
• Riboflavin (vitamin B2) is a required cofactor for MTHFR and may enhance folate utilization in individuals with the 677TT genotype.*[3]
• Glutathione helps balance oxidative stress that may deplete methylation capacity by competing with SAMe synthesis for cysteine.*[7][2]
• The homocysteine to methionine cycle contributes to the formation of SAMe (S-adenosylmethionine) SAM-e which is central to creatine, neurotransmitter, and DNA methylation pathways.*[2]
Who It’s For
Recommended for individuals looking to support healthy methylation, cardiovascular function, or antioxidant balance.*
Special Features
Combines active methyl donors, essential enzyme cofactors, and antioxidant support into a formula designed for comprehensive homocysteine and one-carbon metabolism support.*
References
1. Jing M et al. J Trace Elem Med Biol. 2015;30:77–82.
2. Bottiglieri T. Am J Clin Nutr. 2002;76(5):1151S–7S.
3. McNulty H et al. Circulation. 2006;113(1):74–80.
4. McNulty H et al. Curr Dev Nutr. 2020;4(1):nzz102.
5. Ubbink JB et al. J Clin Invest. 1996;98(1):177–84.
6. Kalhan S, Hanson R. J Biol Chem. 2012;287(24):19786–91.
7. Wang L et al. Exp Ther Med. 2020;20(2):938–44.
