The amino acid L-5-Hydroxytryptophan (5-HTP) is created from L-Tryptophan in the body, and is a precursor to serotonin and melatonin. Our 5-HTP is derived from a plant source, and is carefully tested to ensure its purity and to guarantee the absence of contaminants.

Advanced NeuroPlus® provides Neumentix™ spearmint complex; NeuroFactor™ coffee plant whole fruit extract; NTFactor® phosphoglycolipid blend; Citicoline, precursor to phosphatidylcholine; Lion's mane mushroom; and American ginseng extract with standardized ginsenoside content.*

Pure, highly concentrated berberine HCl (97%), from non-GMO Indian barberry. Berberine supports healthy cholesterol and blood sugar within normal levels, and a normal balance of microbes in the respiratory and GI tracts.*

CurcuWIN® 500 contains turmeric (Curcuma longa) root extract, concentrated to a minimum of 20% curcuminoids. The UltraSOL Nutrient Delivery System increases relative absorption of total curcuminoids over standard curcumin by 46-times, with higher serum concentrations after 12 hours.* The curcuminoids are preserved in the same profile as found naturally in turmeric.*

CurcuWIN® is a registered trademark of OmniActive Health Techonologies, Ltd.

Two safe, well-studied human child strains of friendly bacteria, Bifidobacterium lactis UABla-12™ and Lactobacillus acidophilus DDS®-1.* Non-dairy, gluten-free, naturally-flavored, delicious cherry chewable tablet. Stable at room temperature - no refrigeration required.

This formula utilizes only non-GMO probiotic strains, which are neither derived from nor produced using genetically modified organisms (GMOs), or their derivatives.

Twelve human probiotic strains to support both upper and lower GI health.* 50 billion CFUs per delayed-release vegetarian capsules.* Non-dairy, gluten-free, and stable at room temperature - no refrigeration required.

This formula utilizes only non-GMO probiotic strains, which are neither derived from nor produced using genetically modified organisms (GMOs), or their derivatives.

Six human probiotic strains to support both upper and lower GI health, in senior adults.* 25 billion CFUs per delayed-release vegetarian capsule.* Non-dairy, gluten-free, and stable at room temperature - no refrigeration required.

This formula utilizes only non-GMO probiotic strains, which are neither derived from nor produced using genetically modified organisms (GMOs), or their derivatives.

Ten human probiotic strains, especially formulated for women, including L. crispatus.* 25 billion CFUs per delayed-release vegetarian capsule. Non-dairy, gluten-free, and stable at room temperature - no refrigeration required.

This formula utilizes only non-GMO probiotic strains, which are neither derived from nor produced using genetically modified organisms (GMOs), or their derivatives.

High dose biotin. Biotin is an essential coenzyme for a variety of carboxylation reactions, including the activation of acetylCoA carboxylase, a crucial enzyme in the normal, healthy synthesis of myelin.* Gluten Free!

Iodoral® is a tablet form of Lugol solution. One 12.5 mg tablet of Iodoral® supplies an amount of total elemental iodine comparable to the average daily intake of this essential element by mainland Japanese.*

General Information
Iodine is an essential element. Although its main function is in the production of thyroid hormones by the thyroid gland, other organs in the body have a need for iodine in order to function normally.*(4) 

Several studies have demonstrated a need for iodine intake.*(1,2) The minimum amount of iodine determined in these studies is equivalent to 0.1 mg/kg body weight/day.* For example, for a 50 kg woman, the daily amount of iodine would be 5 mg.* The thyroid gland needs iodide to function properly. The original study done 80 years ago in adolescent girls used 9 mg iodide daily.*(3) 

During the early 1900's, the iodine/iodide solution called Lugol solution was used extensively, effectively and safely in medical practice, for both low activity and above normal activity of the thyroid gland.*(4) The recommended daily intake for iodine supplementation was 2 to 6 drops of Lugol solution, providing 12.5 to 37.5 mg total iodide. That amount was mentioned as lately as 1995 in a book on Pharmaceutical Sciences.(5) 

Several investigators have shown convincing evidence for the need for adequate iodine intake.*(6) Japanese women living in Japan consumed a daily average of 13.8 mg total elemental iodine and some research suggests this is an important factor for their relative health.*(6) In the 1960's, one slice of bread in the USA contained the full RDA of 0.15 mg iodine. Over the last 2 decades, iodine was replaced by bromine in the bread making process. Bromine may block thyroid function and may interfere with iodine in the body.*(4),(7) 

The RDA limits for vitamins and minerals were established after World War II. One of the last essential elements included in the RDA system was iodine, established in 1980 and confirmed in 1989.(8) The RDA for iodine was based on the amount of iodine/iodide needed to prevent goiter, extreme stupidity and hypothyroidism.*(9) The optimal requirement of the whole human body for iodine has never been studied. Therefore, the optimal amount of this element for physical and mental wellbeing is unknown. Based on demographic studies, the mainland Japanese consumed an average of 13.8 mg daily and they are one of the healthiest people on planet earth.*(6) Lugol solution is a time-tested preparation with a proven track record for over 150 years.* Two drops contain 12.5 mg iodine/iodide, an amount very close to the 13.8 mg average intake of mainland Japanese.* 

Rationale For This Formulation
Administration of iodine/iodide in liquid solution is not very accurate, may stain clothing, has an unpleasant taste and can cause gastric irritation. Iodoral® is a precisely quantified tablet form containing 5 mg iodine and 7.5 mg iodide as the potassium salt. To prevent gastric irritation, the iodine/iodide preparation is absorbed into a colloidal silica excipient, and to eliminate the unpleasant taste of iodine, the tablets are coated with a thin film of pharmaceutical glaze.*(10)

References:
1. Ghent, W., et al, Can. J. Surg., 36:453-460,1993.
2. Eskin, B., et al, Biological Trace Element Research, 49:9-19, 1995.
3. Marine, D., Atl. Med. J., 26:437-442, 1923.
4. Abraham,G.E., The Original Internist, 11:17-36, 2004.
5. Gennaro A.R., Remington: 19th Edition, 1995, Mack Publishing Co, 1267.
6. Abraham, G.E., Flechas, J.D., Hakala, J.C., The Original Internist, 9:30-41, 2002.
7. Epstein, S.S., et al, Prevention Program Macmillan, NY, 1998, pg5.
8. Abraham, G.E., The Original Internist, 11:(2) 29-38, 2004.
9. Abraham, G.E. Townsend Letter, 245:100-101, 2003.
10. Abraham, G.E., Flechas, J.D., Hakala, J.C., The Original Internist, 9:5-20, 2002.

High Potency Iodoral® IOD-50 is an iodine/potassium iodide supplement that supplies 50 mg elemental iodine.

General Information
Iodine is an essential element. Although its main function is in the production of thyroid hormones by the thyroid gland, other organs in the body have a need for iodine in order to function normally.*(4) 

Several studies have demonstrated a need for iodine intake.*(1,2) The minimum amount of iodine determined in these studies is equivalent to 0.1 mg/kg body weight/day.* For example, for a 50 kg woman, the daily amount of iodine would be 5 mg.* The thyroid gland needs iodide to function properly. The original study done 80 years ago in adolescent girls used 9 mg iodide daily.*(3) 

During the early 1900's, the iodine/iodide solution called Lugol solution was used extensively, effectively and safely in medical practice, for both low activity and above normal activity of the thyroid gland.*(4) The recommended daily intake for iodine supplementation was 2 to 6 drops of Lugol solution, providing 12.5 to 37.5 mg total iodide. That amount was mentioned as lately as 1995 in a book on Pharmaceutical Sciences.(5) 

Several investigators have shown convincing evidence for the need for adequate iodine intake.*(6) Japanese women living in Japan consumed a daily average of 13.8 mg total elemental iodine and some research suggests this is an important factor for their relative health.*(6) In the 1960's, one slice of bread in the USA contained the full RDA of 0.15 mg iodine. Over the last 2 decades, iodine was replaced by bromine in the bread making process. Bromine may block thyroid function and may interfere with iodine in the body.*(4),(7) 

The RDA limits for vitamins and minerals were established after World War II. One of the last essential elements included in the RDA system was iodine, established in 1980 and confirmed in 1989.(8) The RDA for iodine was based on the amount of iodine/iodide needed to prevent goiter, extreme stupidity and hypothyroidism.*(9) The optimal requirement of the whole human body for iodine has never been studied. Therefore, the optimal amount of this element for physical and mental wellbeing is unknown. Based on demographic studies, the mainland Japanese consumed an average of 13.8 mg daily and they are one of the healthiest people on planet earth.*(6) Lugol solution is a time-tested preparation with a proven track record for over 150 years.* Two drops contain 12.5 mg iodine/iodide, an amount very close to the 13.8 mg average intake of mainland Japanese.* 

Rationale For This Formulation
Administration of iodine/iodide in liquid solution is not very accurate, may stain clothing, has an unpleasant taste and can cause gastric irritation. Iodoral® is a precisely quantified tablet form containing 5 mg iodine and 7.5 mg iodide as the potassium salt. To prevent gastric irritation, the iodine/iodide preparation is absorbed into a colloidal silica excipient, and to eliminate the unpleasant taste of iodine, the tablets are coated with a thin film of pharmaceutical glaze.*(10)

References:
1. Ghent, W., et al, Can. J. Surg., 36:453-460,1993.
2. Eskin, B., et al, Biological Trace Element Research, 49:9-19, 1995.
3. Marine, D., Atl. Med. J., 26:437-442, 1923.
4. Abraham,G.E., The Original Internist, 11:17-36, 2004.
5. Gennaro A.R., Remington: 19th Edition, 1995, Mack Publishing Co, 1267.
6. Abraham, G.E., Flechas, J.D., Hakala, J.C., The Original Internist, 9:30-41, 2002.
7. Epstein, S.S., et al, Prevention Program Macmillan, NY, 1998, pg5.
8. Abraham, G.E., The Original Internist, 11:(2) 29-38, 2004.
9. Abraham, G.E. Townsend Letter, 245:100-101, 2003.
10. Abraham, G.E., Flechas, J.D., Hakala, J.C., The Original Internist, 9:5-20, 2002.

Full spectrum essential fatty acids, including EPA, DHA, GLA, and unmodified hemp oil with naturally occurring phytocannabinoids, enhanced with sunflower lecithin.*

Pycnogenol® is the original French maritime pine bark extract, providing a unique combination of procyanidins, bioflavonoids, and phenolic acids. More than 400 published studies and review articles demonstrate its safety and efficacy.*

Vitamin D3 Complete 5000 is formulated to respect the crucial importance of balancing vitamin D with vitamin A, especially for those who know they require extra vitamin D.* It also contains the other oil-soluble vitamins, K2 (menaquinone-7) and DeltaGOLD® tocotrienols (part of the vitamin E family).*

Vitamin D3 Complete 5000 is in a natural base of sustainably sourced palm oil, and is encapsulated in state-of-the-art fish gelatin capsules.

Zen Adapt enhances the parasympathetic nervous system balancing action of GABA and L-Theanine with the addition of Sensoril®, a pure water extract of ashwagandha, an Ayurvedic herb well known for its ability to help the body function under stress.* Sensoril® has been shown to help alleviate the physical, emotional, and mental effects of stress and tension.*

Zen Sleep includes the same amounts of GABA and L-theanine as the best-selling 200 mg of Zen, augmented with vitamin B6 as pyridoxal-5-phosphate (P5P) and L-5-hydroxytryptophan (5-HTP), the precursor to serotonin and melatonin. The combination helps promote a relaxed state, and provides the necessary factors for the body to produce melatonin, supporting normal, healthy sleep.*