The amino acid L-5-Hydroxytryptophan (5-HTP) is created from L-Tryptophan in the body, and is a precursor to serotonin and melatonin. Our 5-HTP is derived from a plant source, and is carefully tested to ensure its purity and to guarantee the absence of contaminants.

Advanced NeuroPlus® provides Neumentix™ spearmint complex; NeuroFactor™ coffee plant whole fruit extract; NTFactor® phosphoglycolipid blend; Cognizin® Citicoline, precursor to phosphatidylcholine; Lion's mane mushroom; and American ginseng extract with standardized ginsenoside content.*

A balanced antioxidant complex featuring SelenoExcell®, a high-selenium compound from yeast, and Spectra™, a blend of coffee, green tea, fruit, vegetable, herb, and spice extracts and concentrates. Mixed carotenoids, vitamin C, vitamin E, zinc, NAC, and R-lipoic acid complete the formula. Contains less than 1 mg of caffeine per capsule.

AstaZine® astaxanthin is derived from of the organic microalgae Haematococcus pluvialis, grown under sunlight in controlled conditions.* Astaxanthin has been shown to benefit the brain, eyes, muscles, skin, heart, blood vessels, and internal organs.*

Pure, highly concentrated berberine HCl (97%), from non-GMO Indian barberry. Berberine supports healthy cholesterol and blood sugar within normal levels, and a normal balance of microbes in the respiratory and GI tracts.*

Pomegranate, Bergamot citrus, and unripe apple extracts with standardized polyphenol content. Pomella®, Bergavit® 40, and ApplePhenon® support healthy cardiovascular function and normal, healthy cholesterol levels.*

CurcuWIN® 500 contains turmeric (Curcuma longa) root extract, concentrated to a minimum of 20% curcuminoids. The UltraSOL Nutrient Delivery System increases relative absorption of total curcuminoids over standard curcumin by 46-times, with higher serum concentrations after 12 hours.* The curcuminoids are preserved in the same profile as found naturally in turmeric.*

Liquid fish oil, concentrated to 48% long-chain ω-3 fatty acids EPA and DHA, as well as approximately 5% docosapentaenoic acid (DPA).

Twelve human probiotic strains to support both upper and lower GI health.* 50 billion CFUs per delayed-release vegetarian capsules.* Non-dairy, gluten-free, and stable at room temperature - no refrigeration required.

This formula utilizes only non-GMO probiotic strains, which are neither derived from nor produced using genetically modified organisms (GMOs), or their derivatives.

Clinically studied Lactobacillus reuteri NCIMB 30242 (LRC™) with CoQ10 in delayed-release capsules (DRcaps™).* In addition to gastrointestinal benefits, this combination provides synergistic support for the cardiovascular system, and helps support healthy cholesterol levels within the normal level.* Non-dairy, gluten free, stable at room temperature.

Six human probiotic strains to support both upper and lower GI health, in senior adults.* 25 billion CFUs per delayed-release vegetarian capsule.* Non-dairy, gluten-free, and stable at room temperature - no refrigeration required.

This formula utilizes only non-GMO probiotic strains, which are neither derived from nor produced using genetically modified organisms (GMOs), or their derivatives.

A synergistic blend of PreticX™ xylooligosaccharides (XOS) with two clinically tested probiotic strains, Lactobacillus acidophilus DDS®-1 and Bifidobacterium lactis UABla-12™.*

PreticX ™ is a trademark of AIDP, Inc.

DDS® and UABla-12™ are trademarks of UAS Laboratories LLC and used under license.

Ten human probiotic strains, especially formulated for women, including L. crispatus.* 25 billion CFUs per delayed-release vegetarian capsule. Non-dairy, gluten-free, and stable at room temperature - no refrigeration required.

This formula utilizes only non-GMO probiotic strains, which are neither derived from nor produced using genetically modified organisms (GMOs), or their derivatives.

Supports the GI tract, with zinc carnosine, aloe vera extract, and vegan N-acetyl glucosamine.* Also provides rutin, quercetin, and vitamin E. Replaces GastroCort II.

A combination of berberine, milk thistle, choline, and vitamin E to support healthy liver and metabolic function.* Choline supports healthy hepatocyte and gallbladder function.* Berberine supports healthy glucose and cholesterol metabolism, as well as healthy levels of hepatic fat content.* Milk thistle helps protect hepatocytes from oxidative stress, and supports detoxification and healthy metabolic function.* Vitamin E provides antioxidant protection.*

Adaptogens ashwagandha, holy basil, and rhodiola, with licorice and ginger. Each of the clinically studied adaptogenic herbs supports physical function, a balanced mood, and a healthy response to stress.*

High dose biotin. Biotin is an essential coenzyme for a variety of carboxylation reactions, including the activation of acetylCoA carboxylase, a crucial enzyme in the normal, healthy synthesis of myelin.* Gluten Free!

Joint-Skin contains SCP-II® salmon nasal cartilage, naturally extracted from sustainably caught wild salmon. Each capsule contains 6.5 mg undenatured type II collagen and 5 mg undenatured proteoglycans. Joint-Skin supports the health and hydration of connective tissue, joints, and skin.*

Carnipure™ L-Carnitine is the purest form, clinically tested, and vegetarian. L-Carnitine is a non-essential amino acid that helps to maintain overall good health by facilitating the transfer of fatty acid groups into the mitochondrial membrane for cellular energy production.*

Fast-acting melatonin liquid with liposomal delivery for improved bioavailability and prolonged retention in the body, supporting a normal melatonin cycle through the night.*

Specialized magnesium formulated to create hydrogen when added to non-carbonated water. Water infused with hydrogen provides powerful support for antioxidant activity and redox balance.*

A blend of botanicals and nutrients to target psychological well-being, a healthy mood, and a balanced response to stress.* With rhodiola, SaffSerene™ saffron extract, vitamin B6 as P5P, magnesium bisglycinate, and taurine.

Targets arterial flexibility, endothelial function, and healthy blood flow with nutrients that support nitric oxide production.*

High Potency Iodoral® IOD-50 is an iodine/potassium iodide supplement that supplies 50 mg elemental iodine.

General Information
Iodine is an essential element. Although its main function is in the production of thyroid hormones by the thyroid gland, other organs in the body have a need for iodine in order to function normally.*(4) 

Several studies have demonstrated a need for iodine intake.*(1,2) The minimum amount of iodine determined in these studies is equivalent to 0.1 mg/kg body weight/day.* For example, for a 50 kg woman, the daily amount of iodine would be 5 mg.* The thyroid gland needs iodide to function properly. The original study done 80 years ago in adolescent girls used 9 mg iodide daily.*(3) 

During the early 1900's, the iodine/iodide solution called Lugol solution was used extensively, effectively and safely in medical practice, for both low activity and above normal activity of the thyroid gland.*(4) The recommended daily intake for iodine supplementation was 2 to 6 drops of Lugol solution, providing 12.5 to 37.5 mg total iodide. That amount was mentioned as lately as 1995 in a book on Pharmaceutical Sciences.(5) 

Several investigators have shown convincing evidence for the need for adequate iodine intake.*(6) Japanese women living in Japan consumed a daily average of 13.8 mg total elemental iodine and some research suggests this is an important factor for their relative health.*(6) In the 1960's, one slice of bread in the USA contained the full RDA of 0.15 mg iodine. Over the last 2 decades, iodine was replaced by bromine in the bread making process. Bromine may block thyroid function and may interfere with iodine in the body.*(4),(7) 

The RDA limits for vitamins and minerals were established after World War II. One of the last essential elements included in the RDA system was iodine, established in 1980 and confirmed in 1989.(8) The RDA for iodine was based on the amount of iodine/iodide needed to prevent goiter, extreme stupidity and hypothyroidism.*(9) The optimal requirement of the whole human body for iodine has never been studied. Therefore, the optimal amount of this element for physical and mental wellbeing is unknown. Based on demographic studies, the mainland Japanese consumed an average of 13.8 mg daily and they are one of the healthiest people on planet earth.*(6) Lugol solution is a time-tested preparation with a proven track record for over 150 years.* Two drops contain 12.5 mg iodine/iodide, an amount very close to the 13.8 mg average intake of mainland Japanese.* 

Rationale For This Formulation
Administration of iodine/iodide in liquid solution is not very accurate, may stain clothing, has an unpleasant taste and can cause gastric irritation. Iodoral® is a precisely quantified tablet form containing 5 mg iodine and 7.5 mg iodide as the potassium salt. To prevent gastric irritation, the iodine/iodide preparation is absorbed into a colloidal silica excipient, and to eliminate the unpleasant taste of iodine, the tablets are coated with a thin film of pharmaceutical glaze.*(10)

References:
1. Ghent, W., et al, Can. J. Surg., 36:453-460,1993.
2. Eskin, B., et al, Biological Trace Element Research, 49:9-19, 1995.
3. Marine, D., Atl. Med. J., 26:437-442, 1923.
4. Abraham,G.E., The Original Internist, 11:17-36, 2004.
5. Gennaro A.R., Remington: 19th Edition, 1995, Mack Publishing Co, 1267.
6. Abraham, G.E., Flechas, J.D., Hakala, J.C., The Original Internist, 9:30-41, 2002.
7. Epstein, S.S., et al, Prevention Program Macmillan, NY, 1998, pg5.
8. Abraham, G.E., The Original Internist, 11:(2) 29-38, 2004.
9. Abraham, G.E. Townsend Letter, 245:100-101, 2003.
10. Abraham, G.E., Flechas, J.D., Hakala, J.C., The Original Internist, 9:5-20, 2002.

Pau D-Arco Complex provides ingredients that may help to support a healthy balance of intestinal bacteria.* These include Pau D'Arco, Black Walnut, Oregano Oil, Biotin, and Caprylic Acid.

Pycnogenol® is the original French maritime pine bark extract, providing a unique combination of procyanidins, bioflavonoids, and phenolic acids. More than 400 published studies and review articles demonstrate its safety and efficacy.*

Pure concentrated sodium selenite solution (liquid). The daily sodium intake in sodium selenite is nutritionally insignificant.

Vitamin D3 Complete 5000 is formulated to respect the crucial importance of balancing vitamin D with vitamin A, especially for those who know they require extra vitamin D.* It also contains the other oil-soluble vitamins, K2 (menaquinone-7) and DeltaGOLD® tocotrienols (part of the vitamin E family).*

Vitamin D3 Complete 5000 is in a natural base of medium chain triglycerides, and is encapsulated in state-of-the-art fish gelatin capsules.

Zen Adapt enhances the parasympathetic nervous system balancing action of GABA and L-Theanine with the addition of Sensoril®, a pure water extract of ashwagandha, an Ayurvedic herb well known for its ability to help the body function under stress.* Sensoril® has been shown to help alleviate the physical, emotional, and mental effects of stress and tension.*

Contains Suntheanine®, pure L-theanine from Taiyo International, Inc.
Sensoril® is protected under U.S. Patent No. 7,318,938 and CA Patent No. 2,508,478, and is a registered trademark of Natreon, Inc.

Zen Sleep includes the same amounts of GABA and L-theanine as the best-selling 200 mg of Zen, augmented with vitamin B6 as pyridoxal-5-phosphate (P5P) and L-5-hydroxytryptophan (5-HTP), the precursor to serotonin and melatonin. The combination helps promote a relaxed state, and provides the necessary factors for the body to produce melatonin, supporting normal, healthy sleep.*