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Why healthspan is the new focus of geroscience
“Life is short, and the older you get, the more you feel it. Indeed, the shorter it is.” This quote by actor Viggo Mortensen sums up how many people feel when they reach middle age and beyond. They start to realize how important it is to use the time they have wisely, and also that they best heed their body’s physical cues lest they want to hobble around all day after intense physical exertion.
At the same time, life is long. As noted in a documentary titled The Healthspan Imperative, the human race has enjoyed an unprecedented increase in lifespan over the last century. Through advances in medical science, many can expect to live life well into their 80s, 90s, and beyond.
But this increase in longevity has not come without consequences. A substantial part of life now occurs over the age of 65, when the risk for frailty and disease increases exponentially. Eighty-six percent of older adults have at least one chronic health condition, such as hypertension, coronary heart disease, diabetes, cancer, arthritis, hepatitis, weak or failing kidneys, asthma, and/or COPD (chronic obstructive pulmonary disease). Moreover, 60% of older adults are battling two or even three of these conditions.
Aging and its diseases are inseparable, as these diseases are manifestations of aging.
To address this “Silver Tsunami” of disease and disability there is an increasing focus on healthspan, a term that refers to the period of life spent in good health and free from the chronic diseases and disabilities of aging., Healthspan research is based on the concept that chronic, age-related conditions, including heart disease, cancer, and dementia, all share the same trigger: aging itself.,, As one researcher puts it, “Aging and its diseases are inseparable, as these diseases are manifestations of aging.” Thus, if we can slow down the underlying processes that define aging, such as oxidative stress and inflammation, we should be able to delay the development of many diseases.
While the definition and measurement of healthspan needs refinement, there is broad agreement that delaying the onset of disease, and expanding the period of life spent in good health, is of the utmost priority. Some groups are searching for drugs that can inhibit key biological pathways, while others are investigating the influences of lifestyle and nutrition.
The New England Centenarian Study, the largest comprehensive study of centenarians in the world, found that individuals who reach the age of 100 and beyond manage to delay disability towards the very end of their lives.,, By studying their genetics and habits, we may be able to glean the secrets behind their long and healthy lives. While genetics plays an important role in healthspan,, the main attributes that healthy elderly people share is that they have very good lifestyle choices, as discussed below.
Lifestyle is a key determinant of aging
Many of us have the capacity to make it into our early 90s, without chronic disease, by adopting healthy habits.,, One study found that people ages fifty and older who had never smoked and were not obese, and who consumed alcohol moderately, delayed the onset of disability for up to six years as compared to the population overall. And another study showed that people aged 70 to 90 years who adhered to a Mediterranean diet, were physically active, refrained from smoking and consumed alcohol moderately, had a 50% reduction in mortality from all causes.
Social connections and intellectual activities strongly influence healthspan. Even though they are more commonly associated with psychological effects, their physiological effects are also substantial. Individuals living in so-called Blue Zones, areas around the world where centenarians are concentrated, have not only healthy lifestyles but also strong social networks.
In a small town in Minnesota (Albert Lea; population 9000) where Blue Zone practices were implemented – including a central community walking path, which not only encourages daily activity but also is a place where one runs into friends and neighbors, and improving food selections at restaurants and grocery stores – there was a 3.2-year increase in life expectancy after only 18 months, and health care costs dropped by 40%.
Physical activity is essential
“Developing ways to limit sedentary time and increase activity at any level could considerably improve health and reduce mortality,” say the authors of a 2019 study.
Skeletal muscle mass and strength decline as we age, but the rate of decline is greater in those who are sedentary. Muscle weakness is associated with a significantly increased risk of metabolic syndrome, heart disease, Alzheimer’s disease, and all-cause mortality and disability., Regular exercise can help stave off a large number of age-related conditions.,,
Together with physical activity, it’s important to consume enough dietary protein. Aging muscles develop anabolic resistance, which means they do not respond as well to the presence of essential amino acids., Consuming high-quality proteins, such as fish, soy, and whey protein, helps support muscle protein synthesis as we age.,,
Consuming high-quality proteins, such as fish, soy, and whey protein, helps support muscle protein synthesis as we age.
What do healthy centenarians eat?
Calorie restriction has been in the news as a possible strategy to increase lifespan and delay disability., Although maintaining a healthy body weight is desirable, extreme calorie restriction seems to impair the body’s ability to fight infections and to heal from injury. Healthy centenarians maintain a low-normal body weight by eating moderately, for example by putting down their forks when they are 80% full, and by moving more.,
Most healthy centenarians consume plant-based dietary patterns that include a variety of fruits, vegetables, legumes, nuts, and whole grains, and often include fish., Such diets provide high levels of dietary fiber, antioxidants, unsaturated fatty acids, polyphenols, and vitamins, all of which help reduce the risk for age-related diseases and disability.,,,
A study of adults aged 49 years and older found that participants with the highest dietary fiber intakes had the greatest odds of aging healthfully, compared to those consuming low fiber diets. “These findings suggest that increasing intake of fiber-rich foods could be a successful strategy in reaching old age disease-free and fully functional,” say the authors. Even in midlife, healthy dietary changes (increasing vegetables and fruits, improving quality of fats, decreasing sugar and salt) were found to be associated with a reduced risk of dementia.
Dietary fiber exerts its benefits, in large part, by keeping the gut microbiota healthy. As we age, the numbers of beneficial bacteria and overall diversity decline, while harmful species proliferate.,, This imbalance (dysbiosis) contributes to leaky gut, inflammation, and immune dysfunction,, and increases the risk of various age-related diseases.,, Several types of dietary fibers serve as prebiotics— substances that induce the growth or activity of microorganisms that enhance the wellbeing of their host., In addition to a high-fiber diet, supplemental prebiotics, probiotics, or synbiotics (prebiotic/probiotic combinations) are often used to support the microbiome.,,
Dietary fiber exerts its benefits, in large part, by keeping the gut microbiota healthy.
The importance of micronutrients for healthy aging
Insufficient levels of micronutrients, including vitamins B12, C, D, E, iron, and zinc are relatively common in older adults.,, Even on the Mediterranean diet, for example, 80 to 90% of adults do not meet recommended intakes for vitamin D., Nutrient absorption also can decline due to an age-related reduction in stomach acid.,, Among other problems, low absorption contributes to vitamin B12 deficiency, anemia, and peripheral neuropathy.,
Vitamin and mineral deficiencies in older adults are related to increased risks of disability and age-related diseases.
Vitamin and mineral deficiencies in older adults are related to increased risks of disability and age-related diseases. Although many nutrients are important for healthy aging, some of the most notable include:
Vitamin D: Vitamin D is believed to be a primary anti-aging nutrient due to its numerous positive effects in laboratory, animal, and human studies.,,, Vitamin D levels decline with age, and low levels are associated with an increased risk for osteoporosis,, respiratory infections, metabolic syndrome, heart disease,, breast cancer, and Alzheimer’s disease. Since many adults (not just the elderly) are chronically deficient in vitamin D, supplementation may reduce these risks.,,
Antioxidants: Cellular antioxidant levels decline with age., A Japanese study of more than 2000 older women found that diets with high amounts of antioxidants and high protein levels may be an effective strategy for frailty prevention. Antioxidant nutrients such as vitamin E (tocopherols and the corresponding tocotrienols) and coenzyme Q10 (CoQ10) seem to be particularly important for aging muscles and the heart., Growing evidence also supports a role for additional antioxidant nutrients, including lutein, zeaxanthin, and astaxanthin, in the support of eye health and vision.,,
Omega-3 fatty acids: Omega-3 polyunsaturated fatty acids, which are associated with heart health, help support the brain during aging. Individuals who consume diets enriched with omega-3 fatty acids have a reduced risk of Parkinson’s and Alzheimer’s disease. The authors of the latter study advised that “supplementation needs to be a part of a global lifestyle intervention and has to take place in the early stages of the disease, when a benefit may be detected.”
B vitamins: Low vitamin B12, B6, and folate levels increase blood homocysteine levels, thereby increasing the risk for stroke. In fact, brain vitamin B12 levels decline nearly threefold with advancing age. Low B12 and folate levels can also increase the risk for cognitive impairment., Intervention trials in older individuals with cognitive impairment have shown that B vitamin supplementation not only lowers homocysteine, but markedly slows the rate of brain atrophy and cognitive decline.,,, Research also suggests that these B-vitamin-dependent effects can only be realized if there are adequate levels of omega-3 fatty acids.
Life is short, but it also can be very long! The lessons learned from centenarians show that lifestyle, including diet and exercise, is a major determinant of healthspan. Targeted nutritional interventions can not only prevent overt deficiencies, but may also help ward off physical and physiological decline as we age. Nutrients that have been directly linked with healthy aging include high-quality protein, fiber, vitamin D, antioxidants, omega-3 fatty acids, and B vitamins.Click here to see References
 Ward BW, et al. Multiple chronic conditions among US adults: a 2012 update. Prev Chronic Dis. 2014 Apr 17;11:E62.
 Seals DR, et al. Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. J Physiol. 2016 Apr 15;594(8):2001-24.
 Kaeberlein M. How healthy is the healthspan concept? Geroscience. 2018 Aug;40(4):361-4.
 Kennedy BK, et al. Geroscience: linking aging to chronic disease. Cell. 2014 Nov 6;159(4):709-13.
 Niccoli T, Partridge L. Ageing as a risk factor for disease. Curr Biol. 2012 Sep 11;22(17):R741-52.
 Sierra F. The emergence of geroscience as an interdisciplinary approach to the enhancement of health span and life span. Cold Spring Harb Perspect Med. 2016 Apr 1;6(4):a025163.
 Blagosklonny MV. Disease or not, aging is easily treatable. Aging (Albany NY). 2018 Nov 17;10(11):3067-78.
 The New England Centenarian Study. Why study centenarians? An overview [Internet]. Boston (MA): Boston University School of Medicine; 2019 [cited 26 Nov 2019]. Available from: https://www.bumc.bu.edu/centenarian/overview/
 Buettner D, Skemp S. Blue zones: lessons from the world’s longest lived. Am J Lifestyle Med. 2016 Jul 7;10(5):318-21.
 Andersen SL, et al. Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. J Gerontol A Biol Sci Med Sci. 2012 Apr;67(4):395-405.
 Herskind AM, et al. The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum Genet. 1996 Mar;97(3):319-23.
 Christensen K, et al. The quest for genetic determinants of human longevity: challenges and insights. Nat Rev Genet. 2006 Jun;7(6):436-48.
 Larrick JW, Mendelsohn AR. Finally, a regimen to extend human life expectancy. Rejuvenation Res. 2018 Jun;21(3):278-82.
 Li Y, et al. Impact of healthy lifestyle factors on life expectancies in the US population. Circulation. 2018 Jul 24;138(4):345-55.
 Mehta N, Myrskylä M. The population health benefits of a healthy lifestyle: life expectancy increased and onset of disability delayed. Health Affairs. 2017 Jul 19;36(8):1495-502.
 Knoops KT, et al. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. JAMA. 2004 Sep 22;292(12):1433-9.
 Arcos-Burgos M, et al. Neural plasticity during aging. Neural Plast. 2019 Mar 26;2019:6042132.
 Ekelund U, et al. Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis. BMJ. 2019 Aug 21;366:l4570.
 Aversa Z, et al. The clinical impact and biological mechanisms of skeletal muscle aging. Bone. 2019 Oct;127:26-36.
 Jurca R, et al. Association of muscular strength with incidence of metabolic syndrome in men. Med Sci Sports Exerc. 2005 Nov;37(11):1849-55.
 Wu Y, et al. Association of grip strength with risk of all-cause mortality, cardiovascular diseases, and cancer in community-dwelling populations: a meta-analysis of prospective cohort studies. J Am Med Dir Assoc. 2017 Jun 1;18(6):551.
 Camargo EC, et al. Association of physical function with clinical and subclinical brain disease: the Framingham offspring study. J Alzheimers Dis. 2016 Jul 14;53(4):1597-608.
 Bohannon RW. Grip strength: an indispensable biomarker for older adults. Clin Interv Aging. 2019 Oct 1;14:1681-91.
 Musalek C, Kirchengast S.Grip strength as an indicator of health-related quality of life in old age-a pilot study. Int J Environ Res Public Health. 2017 Nov 24;14(12):1447.
 Bethell HJ. Sarcopenia, frailty and exercise. Clin Med (Lond). 2017 Dec;17(6):591.
 Nascimento CM, et al. Sarcopenia, frailty and their prevention by exercise. Free Radic Biol Med. 2019 Feb 20;132:42-9.
 Delaney M, et al. Association and dose-response relationship of self-reported physical activity and disability among adults ≥50 Years: National Health and Nutrition Examination Survey, 2011-2016. J Aging Phys Act. 2019 Nov 21:1-8.
 Mendonça N, et al. Protein intake and disability trajectories in very old adults: the Newcastle 85+ study.
 Franzke B, et al. Dietary protein, muscle and physical function in the very old. Nutrients. 2018 Jul 20;10(7): 935.
 Volpi E, et al. Is the optimal level of protein intake for older adults greater than the recommended dietary allowance? J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):677-81.
 Martinez JA, et al. Physical activity modifies the association between dietary protein and lean mass of postmenopausal women. J Acad Nutr Diet. 2017 Feb;117(2):192-203.
 Børsheim E, et al. Effect of amino acid supplementation on muscle mass, strength and physical function in elderly. Clin Nutr. 2008 Apr;27(2):189-95.
 Liao CD, et al. Effects of protein supplementation combined with exercise intervention on frailty indices, body composition, and physical function in frail older adults. Nutrients. 2018 Dec 4;10(12):1916.
 Huffman DM, et al. Energetic interventions for healthspan and resiliency with aging. Exp Gerontol. 2016 Dec 15;86:73-83.
 Most J, et al. Calorie restriction in humans: an update. Ageing Res Rev. 2017 Oct;39:36-45.
 Willcox DC, et al. Caloric restriction and human longevity: what can we learn from the Okinawans? Biogerontology. 2006 Jun;7(3):173-7.
 Sabia S, et al. Influence of individual and combined healthy behaviours on successful aging. CMAJ. 2012 Dec 11;184(18):1985-92.
 Rajaram S, et al. Plant-based dietary patterns, plant foods, and age-related cognitive decline. Adv Nutr. 2019 Nov 1;10(Supplement 4):S422-36.
 Calder PC, et al. Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing Res Rev. 2017 Nov;40:95-119.
 Chrysohoou C, et al. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: the ATTICA Study. J Am Coll Cardiol. 2004 Jul 7;44(1):152-8.
 Lopez-Garcia E, et al. Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr. 2004 Oct;80(4):1029-35.
 Sindi S, et al. Healthy dietary changes in midlife are associated with reduced dementia risk later in life. Nutrients. 2018 Nov 3;10(11): 1649.
 Gopinath B, et al. Association between carbohydrate nutrition and successful aging over 10 years. J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1335-40.
 Yatsunenko T, et al. Human gut microbiome viewed across age and geography. Nature. 2012 May 9;486(7402):222-7.
 Xu C, et al. Aging progression of human gut microbiota. BMC Microbiol. 2019 Oct 28;19(1):236.
 Kim S, et al. The gut microbiota and healthy aging: a mini-review. Gerontology. 2018;64(6):513-20.
 Buford TW. (Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease. Microbiome. 2017 Jul 14;5(1):80.
 Guigoz Y, et al. The inflammatory status of old age can be nurtured from the intestinal environment. Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):13-20.
 Jackson MA, et al. Signatures of early frailty in the gut microbiota. Genome Med. 2016 Jan 29;8(1):8.
 Qi Y, et al. Intestinal permeability biomarker zonulin is elevated in healthy aging. J Am Med Dir Assoc. 2017 Sep 1;18(9):810.
 Choi J, et al. Influence of altered gut microbiota composition on aging and aging-related diseases. J Lifestyle Med. 2018 Jan;8(1):1-7.
 Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients. 2013 Apr 22;5(4):1417-35.
 Pérez Martínez G, et al. Understanding gut microbiota in elderly’s health will enable intervention through probiotics. Benef Microbes. 2014 Sep;5(3):235-46.
 Childs CE, et al. Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study. Br J Nutr. 2014 Jun 14;111(11):1945-56.
 MacFarlane S, et al. Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double-blind, placebo-controlled crossover study. Aliment Pharmacol Ther. 2013 Oct;38(7):804-16.
 Liu Y, et al. An in vitro approach to study effects of prebiotics and probiotics on the faecal microbiota and selected immune parameters relevant to the elderly. PLoS One. 2016 Sep 9;11(9):e0162604.
 Montgomery SC, et al. Micronutrient needs of the elderly. Nutr Clin Pract. 2014 Aug;29(4):435-44.
 Drenowski A, Shultz JM. Impact of aging on eating behaviors, food choices, nutrition, and health status. J Nutr Health Aging. 2001;5(2):75-9.
 High KP. Nutritional strategies to boost immunity and prevent infection in elderly individuals. Clin Infect Dis. 2001 Dec 1;33(11):1892-900.
 Castiglione D, et al. Dietary micronutrient and mineral intake in the Mediterranean Healthy Eating, Ageing, and Lifestyle (MEAL) Study. Antioxidants (Basel). 2018 Jun 23;7(7):79.
 Castro-Quezada I, et al. The Mediterranean diet and nutritional adequacy: a review. Nutrients. 2014 Jan 3;6(1):231-48.
 Troesch B, et al. The role of vitamins in aging societies. Int J Vitam Nutr Res. 2012 Oct;82(5):355-9.
 Sipponen P, Maaroos HI. Chronic gastritis. Scand J Gastroenterol. 2015 Jun;50(6):657-67.
 Russell RM. Factors in aging that effect the bioavailability of nutrients. J Nutr. 2001 Apr;131(4 Suppl):1359S-61S.
 Yang GT, et al. Correlation between serum vitamin B12 level and peripheral neuropathy in atrophic gastritis. World J Gastroenterol. 2018 Mar 28;24(12):1343-52.
 Pennypacker LC, et al. High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc. 1992 Dec;40(12):1197-204.
 Lozano Relaño M, et al. Nutrients associated with diseases related to aging: a new healthy aging diet index for elderly population. Nutr Hosp. 2018 Dec 3;35(6):1287-97.
 Son DH, et al. Recent advances in anti-aging medicine. Korean J Fam Med. 2019 Sep;40(5):289-96.
 Berridge MJ. Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis. J Physiol. 2017 Nov 15;595(22):6825-36.
 Ashkapin VV, et al. Are there common mechanisms between the Hutchinson-Gilford progeria syndrome and natural aging? Front Genet. 2019 May 15;10:455.
 Chen L, et al. Effects of vitamin D3 supplementation on epigenetic aging in overweight and obese African Americans with suboptimal vitamin D status: a randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):91-8.
 Johnson MA, Kimlin MG. Vitamin D, aging, and the 2005 Dietary Guidelines for Americans. Nutr Rev. 2006 Sep;64(9):410-21.
 Shahnazari B, et al. Comparison of the effect of vitamin D on osteoporosis and osteoporotic patients with healthy individuals referred to the Bone Density Measurement Center. Biomol Concepts. 2019 Apr 3;10(1):44-50.
 Holick MF. Optimal vitamin D status for the prevention and treatment of osteoporosis. Drugs Aging. 2007;24(12):1017-29.
 Zittermann A, et al. Vitamin D and airway infections: a European perspective. Eur J Med Res. 2016 Mar 24;21:14.
 Wang CM, et al. Inverse relationship between metabolic syndrome and 25-hydroxyvitamin D concentration in elderly people without vitamin D deficiency. Sci Rep. 2018 Nov 19;8(1):17052.
 Mirhosseini N, et al. Vitamin D supplementation, serum 25(OH)D concentrations and cardiovascular disease risk factors: a systematic review and meta-analysis. Front Cardiovasc Med. 2018 Jul 12;5:87
 Liu X, et al. The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies. Nutr J. 2019 Nov 14;18(1):73.
 Hossain S, et al. Vitamin D and breast cancer: A systematic review and meta-analysis of observational studies. Clin Nutr ESPEN. 2019 Apr;30:170-84.
 Balion C, et al. Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology. 2012 Sep 25;79(13):1397-405.
 Halfon M, et al. Vitamin D: a review on its effects on muscle strength, the risk of fall, and frailty. Biomed Res Int. 2015;2015:953241.
 Lipowski M, et al. Improvement of attention, executive functions, and processing speed in elderly women as a result of involvement in the Nordic Walking training program and vitamin D supplementation. Nutrients. 2019 Jun 11;11(6):1311.
 Bode LE, et al. Vitamin D supplementation for extraskeletal indications in older persons. J Am Med Dir Assoc. 2019 Nov 18. [Epub ahead of print]
 Martinez de Toda I, et al. Redox parameters as markers of the rate of aging and predictors of lifespan. J Gerontol A Biol Sci Med Sci. 2019 Feb 11. [Epub ahead of print]
 López-Lluch G, et al. The important role of CoQ10 in aging. Antioxidants (Basel). 2019 Nov 20;8(12):570.
 Kobayashi S, et al. Diet with a combination of high protein and high total antioxidant capacity is strongly associated with low prevalence of frailty among old Japanese women: a multicenter cross-sectional study. Nutr J. 2017 May 12;16(1):29.
 Chung E, et al. Potential roles of vitamin E in age-related changes in skeletal muscle health. Nutr Res. 2018 Jan;49:23-36.
 Mortensen SA, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail. 2014 Dec;2(6):641-9.
 Sarmiento A, et al. Coenzyme Q10 supplementation and exercise in healthy humans: a systematic review. Curr Drug Metab. 2016;17(4):345-58.
 Ranard KM, et al. Dietary guidance for lutein: consideration for intake recommendations is scientifically supported. Eur J Nutr. 2017 Dec;56(Suppl 3):37-42.
 Abdel-Aal el-SM, et al. Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health. Nutrients. 2013 Apr 9;5(4):1169-85.
 Otsuka T, et al. Astaxanthin protects against retinal damage: evidence from in vivo and in vitro retinal ischemia and reperfusion models. Curr Eye Res. 2016 Nov;41(11):1465-72.
 Harris WS, et al. Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: the Framingham Heart Study. J Clin Lipidol. 2018 May – Jun;12(3):718-27.
 Cutuli D, et al. Functional and structural benefits induced by omega-3 polyunsaturated fatty acids during aging. Curr Neuropharmacol. 2017;15(4):534-42.
 Avallone R. Omega-3 fatty acids and neurodegenerative diseases: new evidence in clinical trials. Int J Mol Sci. 2019 Aug 30;20(17): 4256.
 Spence JD, et al. Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke. Nutr Res. 2016 Feb;36(2):109-16.
 Zhang Y, et al. Decreased brain levels of vitamin B12 in aging, autism and schizophrenia. PLoS One. 2016 Jan 22;11(1):e0146797.
 An Y, et al. Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1. Clin Epigenetics. 2019 Oct 11;11(1):139.
 Baroni L, et al. Association between cognitive impairment and vitamin B12, folate, and homocysteine status in elderly adults: a retrospective study. J Alzheimers Dis. 2019;70(2):443-53.
 Douaud G, et al. Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9523-8.
 Smith AD, et al. Homocysteine and dementia: an international consensus statement. J Alzheimers Dis. 2018;62(2):561-70.
 Ma F, et al. Effects of folic acid and vitamin B12, alone and in combination on cognitive function and inflammatory factors in the elderly with mild cognitive impairment: a single-blind experimental design. Curr Alzheimer Res. 2019;16(7):622-32.
 Cheng D, et al. B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia. Nutr Neurosci. 2016 Dec;19(10):461-6.
 Jernerén F, et al. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015 Jul;102(1):215-21.
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Marina MacDonald, MS, PhD
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